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2011/12/03 |
ClinL - Omega-3 FAs Reduce Serum C-reactive Protein Concentration |
Original research featuring Nordic Naturals® products
Muhammad K, Morledge t, Saachar R, et al. Treatment with ϖ-3 Fatty Acids Reduces Serum
C-reactive Protein Concentration. Clin. Lipidol. 2011. 6 (6), 723-729.
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BACKGROUND:
Studies have demonstrated that patients with diets high in ϖ-3 fatty acids have a lower risk of adverse cardiovascular events. C-reactive protein (CRP), a marker of inflammation, is a strong predictor of future cardiovascular events. ϖ-3 fatty acids have been shown to have anti-inflammatory properties. However there is a paucity of data examining the effect of ϖ-3 fatty acids on CRP levels. This randomized, double-blind, placebo-controlled trial tested the hypothesis that treatment with ϖ-3 polyunsaturated fatty acids (n-3 PUFAs) would reduce serum high-sensitivity CRP levels.
MATERIALS & METHODS:
Fifty three patients with elevated baseline CRP(>3 mg/l) were randomized to n-3 PUFA (27 patients) or placebo (26 patients). Patients with active infection, inflammatory disease, baseline CRP>10 mg/l or those started on HMG-CoA reductase inhibitor therapy during the study period were excluded. The primary end point was CRP level following 8 weeks of treatment.
RESULTS:
After 8 weeks of treatment with the study drug, the median CRP level in the n-3 PUFA group was 3.4 mg/l compared with 4.0 mg/l in the placebo group (p=0.36). After controlling for baseline CRP, there was a significant percentage decrease in CRP from baseline in the n-3 PUFA group (-40.3%; p = 0.009) but not in the placebo group (-16.4%; p = 0.32)
CONCLUSION:
Treatment for 8 weeks with ϖ-3 fatty acids resulted in a significant percentage reduction of CRP levels as compared with baseline, a finding not seen with placebo.
This study was conducted using Nordic Naturals ProEPA™/EPA™. The dose used was 3 caps/day. |
Source:
http://www.tandfonline.com/doi/pdf/10.2217/clp.11.54
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