Polyunsaturated fatty acids omega-3 (PUFA omega-3), in particular eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), are bioactive lipids that positively impact signaling pathways involved in the development of cardiovascular diseases. PUFA omega-3 affect a myriad of molecular pathways, including

1. alteration physical and chemical properties of membrane microdomains,
2. modulation of membrane receptors and channels,
3. regulation of gene expression via nuclear receptors and transcription factors and
4. changes in eicosanoid clasess' profiles and
5. conversion of EPA and DHA to proresolving mediators.

This review summarizes our current knowledge regarding the mechanism of cardioprotective action of PUFA omega-3.