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2005/07/01 |
OstInt - Vitamin D To Lower Risk Of Fracture |
Dawson-Hughes B, Heaney RP, Holick MF, et al. Estimates of optimal vitamin D status. Osteoporos Int, 2005;16(7):713-716.
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Vitamin D has captured attention as an important determinant of bone health, but there is no common definition of optimal vitamin D status.
Herein, we address the question: What is the optimal circulating level of 25-hydroxyvitamin D [25(OH)D] for the skeleton? The opinions of the authors on the minimum level of serum 25(OH)D that is optimal for fracture prevention varied between 50 and 80 nmol/l. However, for five of the six authors, the minimum desirable 25(OH)D concentration clusters between 70 and 80 nmol/l.
The authors recognize that the average older man and woman will need intakes of at least 20 to 25 mcg (800 to 1,000 IU) per day of vitamin D(3 ) to reach a serum 25(OH)D level of 75 nmol/l.
Based on the available evidence, we believe that if older men and women maintain serum levels of 25(OH)D that are higher than the consensus median threshold of 75 nmol/l, they will be at lower risk of fracture.
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Source:
http://www.ncbi.nlm.nih.gov/pubmed/15776217
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