OBJECTIVE:
To study plasma adiponectin levels in women diagnosed with polycystic ovary syndrome given omega-3 fatty acid supplements.
PATIENTS AND METHODS:
A study was conducted in 195 women diagnosed with polycystic ovary syndrome treated with omega-3 fatty acids for 12weeks (n=97; groupA) and control women given placebo (n=98, groupB). General characteristics, metabolism, lipid profile, and hormone and adiponectin levels were compared.
RESULTS:
There were no significant differences between the two groups in general characteristics. No significant differences were also found in hormone, blood glucose, and HOMA levels between the groups. Women in study groupsA andB showed no statistically significant differences in total calorie, carbohydrate, protein, and total fat intake between the baseline and final values. Decreased total cholesterol, low-density lipoprotein, and triglyceride levels were found in groupA women (P<.0001). Mean of adiponectin levels also showed a statistically significant increase after treatment (P<.0001). There were no statistically significant differences in the mean values of the different variables in groupB women.
CONCLUSION:
Omega-3 fatty acid supplementation for 12weeks caused a significant increase in plasma adiponectin levels in women with polycystic ovary syndrome.