Summary: In a population-based study involving 2,416 adolescents and adults living in New Zealand, results indicate a positive association between
eicosapentaenoic acid (EPA) concentration in serum phospholipids and physical well-being, and between the ratio of EPA to arachidonic acid and self-reported mental well-being. Mental and physical well-being was assessed using the short-form 36 health questionnaire. After adjusting for potential confounders, the proportion of eicosapentaenoic acid and the ratio of eicosapentaenoic acid to arachidonic acid in serum phospholipids were positively associated with self-reported physical well-being. Additionally, a positive association was observed between the ratio of eicosapentaenoic to
arachidonic acid and self-reported mental well-being. However, neither EPA nor DHA (docosahexaenoic acid) were associated with the mental component score. Thus, the authors of this study conclude, "The results from this population-based survey of New Zealand ers suggest a strong and consistent association between eicosapentaenoic acid in serum phospholipids and self-reported physical well-being; the association with mental well-being is less compelling."